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Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1 stabilization by glucose-dependent generation of reactive oxygen species

The therapeutics should 1) not interfere with or promote opioid analgesia, 2) prevent the acquisition of physical dependence and psychological addiction to opioids, 3) block opioid-induced respiratory depression (OIRD), or 4) stop the development of hyperalgesia (Morgan and Christie, 2011

Endothelial dysfunction and its clinical implications

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Rheumatology (Oxford) 58(9):16071616 Trindade TS, Morais CG, Maia A, Rodrigues M, Brito I (2023) Demographic and clinical features of pediatric vasculitis: a single-center study