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Critically, serine-derived one-carbon units sustain S-adenosylmethionine (SAM) production, thereby fueling histone and DNA methylation and potentially reinforcing the epigenetic blockade of myeloid differentiation - positioning PHGDH and the broader one-carbon pathway as candidate therapeutic targets in molecularly defined AML subsets that warrant prospective validation in primary patient material [11,12,42]
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10.1016/0008-8749(91)90147-4 18 GuoY.LiH.LiuZ.LiC.ChenY.JiangC.et al (2019)
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