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ALP-induced cardiovascular disturbances include refractory hypotension, dysrhythmia, and congestive heart failure (Nath et al., 2011

They are not for human or veterinary use and are not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease

Humans cannot synthesize ascorbic acid endogenously and a lack of dietary intake can lead to scurvy

This is proposed to be mediated by TRX1 oxidation by hydrogen peroxide which causes dissociation of ASK1 thereby triggering anti-apoptotic factors via downstream activation of MAPK kinase MKK3/MKK6/p38 and MKK4/MKK7/JNK pathways (Wagner et al

Most patients describe the sensation as a quick pinch with minimal discomfort

10.1038/s41556-020-0461-8 55 LeeH.ZhuangL.GanB