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The bulky ring may cause excessive flexibility or steric hindrance, resulting in poor binding

10.1016/j.neuron.2014.04.034 178 Vicente MirandaH.Szeg

doi: 10.1007/s10753-021-01464-5 333 RoblesJPZamoraMAdan-CastroESiqueiros-MarquezLde la EscaleraGMClappC

This oligomerization processes seems to be evident in other AMPs such as lactoferrin (LTF) (that has been found to aggregate in corneal amyloidosis

The gut GSH system forms an essential antitoxic barrier for mucosa and helps maintain the normal immune functions [97]

PMID: 20618611
