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For oral supplements, the primary concern isn't safety but rather effectiveness given the bioavailability challenges discussed earlier

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Glutathione-based antioxidant support

NRF2, nuclear factor erythroid 2-related factor 2

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In this model, endogenous glutamine production is not sufficient to counteract GSH depletion due to oxidative stress, and exogenous administration attenuates GSH depletion and MDA levels [111]