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doi: 10.1136/jnnp-2022-329024, 41

Arosio E, De Marchi S, Zannoni M, Prior M, Lechi A

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biochemically, there is intracellular glutathione (GSH) depletion and decreased activity of glutathione peroxidase 4 (GPX4), lipid peroxides cannot be metabolized by the GPX4-catalyzed reduction reaction, and Fe 2+ oxidizes lipids in a Fenton-like manner, resulting in a large amount of ROS, which promotes ferroptosis 3,6

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AD is a chronic neurodegenerative disorder representing the most prevalent form of dementia in modern society