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Description
While some studies found no difference between individuals with T2DM and matched non-diabetic controls ( per se and glycaemic control, since it is unclear whether changes in soluble DPP-4 activity in the circulation accurately reflect any changes in total DPP-4 activity
They mimic a hormone that tells the brain "I'm full" and slows down how fast food leaves the stomach, as well as impacts blood sugar control

10.1016/j.mcn.2010.12.004 314

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Essentially, the threshold for quieting inflammatory action / modulating inflammatory signalling may be lower than the threshold for affecting body weight
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